Gene Savvy ClinHeroGI 0 stars, based on 0 reviews 0 5


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Model Number: 000103gs

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Categories: , Specific Affliction
Manufacturer: Gene Savvy
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Genetics and genomics are beginning to strongly influence the care of patients with GI conditions. Exome testing identifies gene / variants associated with functional disturbance, pathways involved and targetable action to facilitate improved function and epigenetic outcomes. The value of this panel of genes is in the actionable clinical evaluation and treatment approach. The following functional disturbances of the GI tract are included in this panel.

IBD:  An inflammatory bowel disease that has material basis in variation in the chromosome region 10q21. This includes Crohn’s Disease, Ulcerative Colitis and Autoimmune Related Colitis. [1][2][3] There are several key variants that are associated with inflammatory risk and actionable movement.

IBS: A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause. [4] In addition, variants identified can outline risk of other possible disease implications that can often be missed in routine diagnosis.

GERD: The retrograde movement of stomach contents into the esophagus characterizes Gastroesophageal reflux Disease (GERD). In its most severe form, GERD results in extensive tissue damage caused by acid reflux. In turn, Barrett metaplasia is correlated with the development of adenocarcinoma of the esophagus, estimated as the fifth most prevalent neoplasia in the Western world. [5] Knowing gene variant patterns can be valuable in precise diagnosis and treatment of the disease. In addition, variants identified can outline risk of other possible disease implications that can often be missed in routine diagnosis.

Nutritional / Mineral Metabolism / Transport / Hydration: The GI tract is responsible of many complex functions including nutrition, hydration, mineral metabolism and transportation of metabolites. Key elements include calcium, potassium, magnesium, copper, zinc and other trace minerals, creatine, purines and pyrroles and citrate to name a few. [6]  Poor hydration in the gut is known to increase risk of GI cancers. [7] Ion transportation is impaired in intestinal inflammation and it is essential in identifying transporting gene variants that are implicated in impaired function. [8]

*All GeneSavvy Genetic tests must be signed for by a physician. If you don’t currently have a physician, we can connect you with a physician after you complete your order to review your health information and submit the needed documents.

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