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Panel Overview. The AutoInflamGS Panel is a unique genetic sequencing service that looks at genes associated with autoinflammatory symptoms (disorders of the innate immune system), such as inflammatory bowel diseases, psoriaisis, periodic fever syndromes, acne inversa, and others. We take a novel approach by providing several types of clinical data for your healthcare professional to evaluate. We perform exon region sequencing for over 35 genes related to inflammation, as well as looking at over 100 single locations (SNVs) related to inflammation, plus another 75 single locations (SNPs) related to general wellness. The AutoInflamGS Panel is performed using the latest next-generation DNA sequencing technology.
Disease-related Gene Sequencing List: ABCB1, AP1S3, ATG16L1, CARD14, COPA, HLA-C, IL10, IL10RA, IL10RB, IL1RN, IL23A, IL23R, IL36RN, IL6, IRF5, IRGM, LPIN2, MEFV, MVK, NCSTN, NLRC4, NLRP12, NLRP3, NOD2, PLCG2, PSENEN, PSMB8, PSTPIP1, PTPN2, TMEM173, TNFAIP3, TNFRSF1A, TRAF3IP2
Disease-related SNV List: 1p31.1a, ACVRL1+, ARMS2–HTRA1, ASTN2+, c7orf10+, CACNA1A, CARF, CFDP1, EDNRA, ENG+, ESR1+, FHL5, FHL5–UFL1+, GRIA1+, GRIA3, HCRTR2, HCTR1+, HEY2–NCOA7, HPSE2, IGSF9B, KCNK18+, KCNN3, LRP1, LRP1–STAT6– SDR9C7, MEF2D+, MPPED2, MRVI1, MTDH, MTHFR+, NBEA, ADAMTSL4–ECM1~, CCM2L–HCK~, DOCK4–IMMP2L~, FGF6~, GJA1~, GPR149~, ITPK1~, JAG1~, MED14–USP9X~, NOTCH4~, REST–SPINK2~, TGFBR2~, TSPAN2–NGF~, WSCD1–NLRP1~, ZCCHC14~, NOS3, NRP1, NSDHL, PHACTR1+, PLCE1, PRDM16+, RNF213, RYR2+, SLC24A3, SLC6A4, STX1A+, TGFBR2, TNF, TRPM8, TRPM8–HJURP+, YAP1
General Wellness SNP List: AANT, ACAT1, ACE, ADM, AHCY+, BDNF, BHMT+, BTD, C5, CBS+, COMT+, CoQ2, CoQ3, COX5A, COX6C, CYP27A1, CYP27B1, DHFR, ENPP1, GSS, GSTM1, GSTP+, IGF1, IL10, IL23R, IL6, IL6R, KCNJ11, MAOA, MAOB, MAT1A, MAT2B, MTHFR+, MTR, MTRR+, NLRP6, NOS, NOS3, PDHA1, PDHB, PEMT, PNMT, PTPN22, PTS, QDPR, SHMT1+, SIRT1, SLC19A1, SLC22A5, SLC25A15, SLC25A32, SLC2A1, SOD2, SULT1A3, SUOX+, TGFB1+, TNF-alpha+, TRAF1, TRAP1, USF1, VDR+
This test was designed to sequence the exons and canonical splice sites (+/1,2) of a panel of genes associated with the clinical management and actionable treatment options of common Autoinflammation symptoms. These genetic variants can be associated with functional disturbance, pathways involved and targetable action to facilitate improved function and epigenetic outcomes. GeneSavvy has developed highly advanced protocols to target and extract variants in exonic regions, intronic regions of interest, splice sites, and untranslated gene regions of interest with the following technical specifications:
- Mean Depth of Coverage: 50x
- Specificity: >98%
- Sensitivity: >94%
*All GeneSavvy Genetic tests must be signed for by a physician. If you don’t currently have a physician, we can connect you with a physician after you complete your order to review your health information and submit the needed documents.